Introns Regulate Gene Expression in Cryptococcus neoformans in a Pab2p Dependent Pathway
Identifieur interne : 004627 ( Main/Exploration ); précédent : 004626; suivant : 004628Introns Regulate Gene Expression in Cryptococcus neoformans in a Pab2p Dependent Pathway
Auteurs : Carolin Goebels [France] ; Aline Thonn [France] ; Sara Gonzalez-Hilarion [France] ; Olga Rolland [France] ; Frederique Moyrand [France] ; Traude H. Beilharz [Australie] ; Guilhem Janbon [France]Source :
- PLoS Genetics [ 1553-7390 ] ; 2013.
Abstract
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Url:
DOI: 10.1371/journal.pgen.1003686
PubMed: 23966870
PubMed Central: 3744415
Affiliations:
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region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Thonn, Aline" sort="Thonn, Aline" uniqKey="Thonn A" first="Aline" last="Thonn">Aline Thonn</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gonzalez Hilarion, Sara" sort="Gonzalez Hilarion, Sara" uniqKey="Gonzalez Hilarion S" first="Sara" last="Gonzalez-Hilarion">Sara Gonzalez-Hilarion</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rolland, Olga" sort="Rolland, Olga" uniqKey="Rolland O" first="Olga" last="Rolland">Olga Rolland</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moyrand, Frederique" sort="Moyrand, Frederique" uniqKey="Moyrand F" first="Frederique" last="Moyrand">Frederique Moyrand</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beilharz, Traude H" sort="Beilharz, Traude H" uniqKey="Beilharz T" first="Traude H." last="Beilharz">Traude H. Beilharz</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Monash University, Department of Biochemistry and Molecular Biology, Clayton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Department of Biochemistry and Molecular Biology, Clayton</wicri:regionArea><wicri:noRegion>Clayton</wicri:noRegion></affiliation></author><author><name sortKey="Janbon, Guilhem" sort="Janbon, Guilhem" uniqKey="Janbon G" first="Guilhem" last="Janbon">Guilhem Janbon</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité des Aspergillus, Département Parasitologie et Mycologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS Genetics</title><idno type="ISSN">1553-7390</idno><idno type="eISSN">1553-7404</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Most <italic>Cryptococccus neoformans</italic> genes are interrupted by introns, and alternative splicing occurs very often. In this study, we examined the influence of introns on <italic>C. neoformans</italic> gene expression. For most tested genes, elimination of introns greatly reduces mRNA accumulation. Strikingly, the number and the position of introns modulate the gene expression level in a cumulative manner. A screen for mutant strains able to express functionally an intronless allele revealed that the nuclear poly(A) binding protein Pab2 modulates intron-dependent regulation of gene expression in <italic>C. neoformans</italic>. <italic>PAB2</italic> deletion partially restored accumulation of intronless mRNA. In addition, our results demonstrated that the essential nucleases Rrp44p and Xrn2p are implicated in the degradation of mRNA transcribed from an intronless allele in <italic>C. neoformans</italic>. Double mutant constructions and over-expression experiments suggested that Pab2p and Xrn2p could act in the same pathway whereas Rrp44p appears to act independently. Finally, deletion of the <italic>RRP6</italic> or the <italic>CID14</italic> gene, encoding the nuclear exosome nuclease and the TRAMP complex associated poly(A) polymerase, respectively, has no effect on intronless allele expression.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sambrook, J" uniqKey="Sambrook J">J Sambrook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wahl, Mc" uniqKey="Wahl M">MC Wahl</name></author><author><name sortKey="Will, Cl" uniqKey="Will C">CL Will</name></author><author><name sortKey="Luhrmann, R" uniqKey="Luhrmann R">R Lührmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Silver, Pa" uniqKey="Silver P">PA Silver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Hir, H" uniqKey="Le Hir H">H Le 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Guilhem" sort="Janbon, Guilhem" uniqKey="Janbon G" first="Guilhem" last="Janbon">Guilhem Janbon</name><name sortKey="Moyrand, Frederique" sort="Moyrand, Frederique" uniqKey="Moyrand F" first="Frederique" last="Moyrand">Frederique Moyrand</name><name sortKey="Rolland, Olga" sort="Rolland, Olga" uniqKey="Rolland O" first="Olga" last="Rolland">Olga Rolland</name><name sortKey="Thonn, Aline" sort="Thonn, Aline" uniqKey="Thonn A" first="Aline" last="Thonn">Aline Thonn</name></country><country name="Australie"><noRegion><name sortKey="Beilharz, Traude H" sort="Beilharz, Traude H" uniqKey="Beilharz T" first="Traude H." last="Beilharz">Traude H. 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